Reagents and instruments for immunology, cell biology and molecular biology.
 
> SC-514 [354812-17-2]

SC-514 [354812-17-2]

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Cat# 10-1054-10mg

Size : 10mg

Brand : Focus Biomolecules

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Phone : +1 850 650 7790

SC-514 | IKK-2 inhibitor

CAS:
354812-17-2
Catalog Number:
10-1054
Activity:
IKK-2 inhibitor
Chemical Name:
5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
Molecular Weight:
224.3
Molecular Formula:
C9H8N2OS2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1

References/Citations:

1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861

SC-514 | IKK-2 inhibitor is also available in the Cellular Metabolism Library.
CAS:
354812-17-2
Catalog Number:
10-1054
Activity:
IKK-2 inhibitor
Chemical Name:
5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
Molecular Weight:
224.3
Molecular Formula:
C9H8N2OS2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1

References/Citations:

1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861