Notch4 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN311127BN
Notch4 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro RFP-BSD
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
| Donor DNA | mBFP-Neo |
| Symbol | Notch4 |
| Locus ID | 18132 |
| Components | KN311127G1, Notch4 gRNA vector 1 in pCas-Guide CRISPR vector KN311127G2, Notch4 gRNA vector 2 in pCas-Guide CRISPR vector KN311127BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_010929 |
| UniProt ID | P31695 |
| Synonyms | Int-3; Int3; N4 |
| Summary | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system.[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN311127 | Notch4 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN311127LP | Notch4 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN311127RB | Notch4 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN511127 | Notch4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA202939 | Notch4 CRISPRa kit - CRISPR gene activation of mouse notch 4 | 1 657,00 EUR |