Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Ascorbic acid sodium salt [134-03-2]
Cat# T6674-1mL
Size : 1mL
Brand : TargetMol
Contact local distributor :
Phone : +1 850 650 7790
L-Ascorbic acid sodium salt
Catalog No. T6674 CAS 134-03-2
Synonyms: (+)-Sodium L-ascorbate, Vitamin C sodium salt, Sodium ascorbate, L-Ascorbic acid sodium, Sodium L-ascorbate
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
All TargetMol products are for research or drug registration purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose in violation of laws and regulations.
L-Ascorbic acid sodium salt, CAS 134-03-2
| Description | L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement. |
| In vitro | Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. [1] Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. [2] Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. [3] Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. [4] |
| In vivo | Tg rats treated with sodium?L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium?L-ascorbate (15.4%). Independent of the sodium?L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5]. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium?L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium?L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6]. |
| Source |
| Synonyms | (+)-Sodium L-ascorbate, Vitamin C sodium salt, Sodium ascorbate, L-Ascorbic acid sodium, Sodium L-ascorbate |
| Molecular Weight | 199.11 |
| Formula | C6H8NaO6 |
| CAS No. | 134-03-2 |
Storage
Solubility Information
DMSO: 6.25 mg/mL (31.39 mM), Sonication is recommended.
H2O: 198.9 mM
References and Literature
1. Noto V, et al. Cancer, 1989, 63(5), 901-906. 2. De Loecker W, et al. Anticancer Res, 1993, 13(1), 103-106. 3. Sakagami H, et al. Life Sci, 1996, 58(14), 1131-1138. 4. Singh NP, et al. Mutat Res, 1997, 375(2), 195-203. 5. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.