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Reagents and instruments for immunology, cell biology and molecular biology.

Heparin sodium [9041-08-1]

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Cat# A5066-100mg

Size : 100mg

Contact local distributor :

Phone : +1 850 650 7790

Brand : ApexBio Technology

Contact local distributor :

Phone : +1 850 650 7790

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Background

Minimum activity: > 150 I.U./mg. Glycosaminoglycan that behaves as an anticoagulant. Binds with high affinity to antithrombin III (AT-III).

Product Citation

1. Yiyi Chen, Jiao Huo, et al. "Development of a novel flow cytometry‐based approach for reticulocytes micronucleus test in rat peripheral blood." J Appl Toxicol. 2021 Apr;41(4):595-606. PMID: 33067908

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	50000
Cas No.	9041-08-1
Solubility	insoluble in EtOH; insoluble in DMSO; ≥12.75 mg/mL in H2O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment:[1]
Animal models	Male New Zealand rabbits with a mean body weight of 2300 ± 300 g
Dosage form	2000 IU heparin Administered by the intravenous route (i.v.)
Applications	Heparin increased both anti-factor Xa activity and activated partial thromboplastin time (aPTT). Heparin (2000 IU, i.v.) showed an AUC_0→24/kg value of 3.30 ± 0.59 IU·h^-1·mL^-1·kg^-1, with 100% absolute bioavailability. Apart from the parenteral route, heparin could also be administered by the oral route when incorporated into polymeric nanoparticles which were able to maintain the anti-Xa activity of heparin for a longer period.
Note	The technical data provided above is for reference only.
	References: 1. Jiao Y, Ubrich N, Marchand-Arvier M, et al. In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation, 2002, 105(2): 230-235.

Quality Control

Purity = 98.00%

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