Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glimepiride [93479-97-1]
Cat# T0127-500mg
Size : 500mg
Brand : TargetMol
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Glimepiride
Catalog No. T0127 CAS 93479-97-1
Synonyms: Glimperide, HOE-490
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
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Glimepiride, CAS 93479-97-1
| Description | Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity. |
| Targets&IC50 | SUR1:3 nM, SUR2A:5.4 nM, SUR2B:7.3 nM |
| In vitro | Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity. |
| In vivo | In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits. |
| Synonyms | Glimperide, HOE-490 |
| Molecular Weight | 490.62 |
| Formula | C24H34N4O5S |
| CAS No. | 93479-97-1 |
Storage
Solubility Information
DMSO: 16.67 mg/mL (33.97 mM)
References and Literature
1. Song DK, et al. Br J Pharmacol, 2001, 133(1), 193-199. 2. Müller G, et al. Horm Metab Res, 1996, 28(9), 469-487 3. Lawrence CL, et al. Br J Pharmacol, 2002, 136(5), 746-752. 4. Rabbani SI, et al. Indian J Exp Biol, 2009, 47(10), 804-810.