Deschloroclozapine [1977-07-7]
Cat# HY-42110-10mg
Size : 10mg
Brand : MedChemExpress
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
For research use only. We do not sell to patients.
Deschloroclozapine Chemical Structure
CAS No. : 1977-07-7
This product is a controlled substance and not for sale in your territory.
Based on 35 publication(s) in Google Scholar
Other Forms of Deschloroclozapine:
- Deschloroclozapine dihydrochloride In-stock
Description |
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging[1][2][3]. |
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IC50 & Target |
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In Vitro |
Designer Receptors Exclusively Activated by Designer Drugs (DREADD) are a chemogenetic approach for remote manipulation of neuronal activity in freely-moving animals. DREADDs comprise mutated G protein-coupled receptors (GPCRs) that do not respond to their endogenous neurotransmitter, but do respond to an otherwise “inert” exogenous substance[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Deschloroclozapine (0.3 mg/kg; intramuscularly) impairs working memory function in male rhesus macaques (aged between 5 and 6 years and weighing 5.5-7.9 kg)[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
292.38 |
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Formula |
C18H20N4 |
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CAS No. |
1977-07-7 |
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Appearance |
Solid |
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Color |
Light yellow to yellow |
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SMILES |
CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (342.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.4202 mL | 17.1010 mL | 34.2021 mL | 85.5052 mL |
5 mM | 0.6840 mL | 3.4202 mL | 6.8404 mL | 17.1010 mL | |
10 mM | 0.3420 mL | 1.7101 mL | 3.4202 mL | 8.5505 mL | |
15 mM | 0.2280 mL | 1.1401 mL | 2.2801 mL | 5.7003 mL | |
20 mM | 0.1710 mL | 0.8551 mL | 1.7101 mL | 4.2753 mL | |
25 mM | 0.1368 mL | 0.6840 mL | 1.3681 mL | 3.4202 mL | |
30 mM | 0.1140 mL | 0.5700 mL | 1.1401 mL | 2.8502 mL | |
40 mM | 0.0855 mL | 0.4275 mL | 0.8551 mL | 2.1376 mL | |
50 mM | 0.0684 mL | 0.3420 mL | 0.6840 mL | 1.7101 mL | |
60 mM | 0.0570 mL | 0.2850 mL | 0.5700 mL | 1.4251 mL | |
80 mM | 0.0428 mL | 0.2138 mL | 0.4275 mL | 1.0688 mL | |
100 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8551 mL |