Cxxc5 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN304060RB
Cxxc5 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
| Donor DNA | RFP-BSD |
| Symbol | Cxxc5 |
| Locus ID | 67393 |
| Components | KN304060G1, Cxxc5 gRNA vector 1 in pCas-Guide CRISPR vector KN304060G2, Cxxc5 gRNA vector 2 in pCas-Guide CRISPR vector KN304060RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_133687, NM_001357458, NM_001357459 |
| UniProt ID | Q91WA4 |
| Synonyms | 4930415K17Rik |
| Summary | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN304060 | Cxxc5 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN304060BN | Cxxc5 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN304060LP | Cxxc5 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN504060 | Cxxc5 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA207305 | Cxxc5 CRISPRa kit - CRISPR gene activation of mouse CXXC finger 5 | 1 657,00 EUR |