CHEK1 Antibody - middle region : Biotin
Cat# ARP32588_P050-Biotin
Size : 100ul
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
CHEK1 Antibody - middle region : Biotin (ARP32588_P050-Biotin)
| Datasheets/Manuals | Printable datasheet for anti-CHEK1 (ARP32588_P050-Biotin) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
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| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | Biotin |
| Application | IHC, WB |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human CHEK1 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: SARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-CHEK1 (ARP32588_P050-Biotin) antibody is Catalog # AAP32588 (Previous Catalog # AAPP03591) |
| Sample Type Confirmation | CHEK1 is strongly supported by BioGPS gene expression data to be expressed in 721_B |
| Reference | Bennett,L.N., (2008) Biochem. Biophys. Res. Commun. 369 (3), 973-976 |
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| Gene Symbol | CHEK1 |
| Gene Full Name | Checkpoint kinase 1 |
| Alias Symbols | CHK1 |
| NCBI Gene Id | 1111 |
| Protein Name | Serine/threonine-protein kinase Chk1 |
| Description of Target | CHEK1 is required during normal S phase to avoid aberrantly increased initiation of DNA replication, thereby protecting against DNA breakage. Its expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. |
| Uniprot ID | O14757 |
| Protein Accession # | NP_001265 |
| Nucleotide Accession # | NM_001274 |
| Protein Size (# AA) | 476 |
| Molecular Weight | 54kDa |
| Protein Interactions | RELA; CUL4A; UBC; SETMAR; DDB1; TNRC6B; ATR; HECW2; CLSPN; DTL; BTG3; TOPBP1; MAPKAPK2; HSP90AA1; CDC25C; RAD51; PIGM; CUL1; VCP; CDC25A; ATM; APP; MED15; NEK2; TLK1; RB1; BRCA1; FEM1B; XIAP; COPS5; MEPE; LATS2; TP53; Chek1; MEN1; USP7; DNMT1; FANCE; PCNA |
