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Reagents and instruments for immunology, cell biology and molecular biology.

Anti-Kv2.1 Potassium Channel Subunit Antibody FL594 Conjugate

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Cat# 75-315-FL594

Size : 200uL

Contact local distributor :

Phone : +1 850 650 7790

Brand : Antibodies Incorporated

Contact local distributor :

Phone : +1 850 650 7790

Our Anti-Kv2.1 potassium channel subunit mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L80/21. It is KO validated, detects human, mouse, and rat Kv2.1 potassium channel subunit, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

550

650

Data Sheet

KO Validated

SKU: 75-315-FL594

Product Details

Target

Kv2.1 potassium channel subunit

Target Description

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

L80/21

Isotype

IgG3

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Antigen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (accession number P15387)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2940102

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt Details

UniProt (Human): Q14721
UniProt (Immunogen Species): P15387

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