75-014-020 | Anti-Kv2.1 K+ Channel Antibody Biotrend

Anti-Kv2.1 K+ Channel Antibody (K89/34)

Our Anti-Kv2.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K89/34. It is KO validated, detects human, mouse, and rat Kv2.1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.

Adult rat hippocampus immunohistochemistry.

Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse. Samples courtesy of Dr. Jeanne Nerbonne, Washington University School of Medicine.

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].

Representative super-resolution Airyscan images taken at a focal plane near the PM of CTL (black) and U18-treated (red) neurons fixed and immunolabeled for KV2.1 (cat. 75-014). Image from publication CC-BY-4.0. PMID:37507375

Representative maximum intensity projections from Wild-Type (WT) (black) and NPC1I1061T (red) cortical sagittal sections stained with Hoechst and immunolabeled for KV2.1 (cat. 75-014, 10ug/ml). Right, quantification of Kv2.1 total intensity, cluster size and cluster density of WT (black) and NPC1I1061T (red) neurons in the soma region. Image from publication CC-BY-4.0. PMID:37507375

Representative maximum intensity projections from WT (black) and NPC1I1061T (red) mouse cerebellar sagittal sections co-immunolabeled for Calbindin(cat. 75-448, 2ug/ml) , CaV1.2 (cat. 75-257, 5ug/ml) and KV2.1 (cat. 75-014, 10ug/ml). Image from publication CC-BY-4.0. PMID:37507375

Representative super-resolution TIRF images of CTL (black) and U18-treated (red) neurons co-immunolabeled for CaV1.2 (cat. 75-257, 5 ug/ml) and KV2.1 (cat. 75-014, 10 ug/ml). Image from publication CC-BY-4.0. PMID:37507375

Representative images of astrocytes labeled by AAV5-GfaABC1D-EBFP and neurons labeled by Kv2.1 (cat. 75-014, 1:100) in the hippocampal CA1sr and VMH. The measurement method of soma diameter is shown on the right. The yellow dashed lines show the three randomly selected branches of each cell. Image from publication CC-BY-4.0. PMID:38137092

Image of cultured hippocampal cells immune-labeled with antibodies specific for Kv2.1 (cat. 75-014, 1:400; green) and GLT-1 showing a pyramidal cell with a portion of the basal surface in contact with a GLT-1a positive astrocyte. The right panel shows an enlargement of the boxed area. Image from publication CC-BY-4.0. PMID:38362041

Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Data Sheet

KO Validated

Trial Size

SKU: 75-014

Product Details

Target

Kv2.1 K+ channel

Target Description

Kv 2.1 K+ channel (Potassium voltage-gated channel subfamily B member 1), which is encoded by KCNB1 gene, is a member of the Potassium voltage-gated channel familly. This protein, mainly expressed in the central nervous system, functions as a delayed rectifier. Indeed, it regulates the action potential (AP) repolarization as well as duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells. Kv2.1 K+ channel switches between open or closed conformation in response to the voltage difference across the membrane. This process directs the voltage-dependent potassium ion permeability of excitable membranes, which lets potassium ions pass in accordance with their electrochemical gradient. Kv2.1 K+ channel is widely used as a marker to measure membrane excitability in hippocampal neurons.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K89/34

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Antigen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (accession number P15387)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10673392

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:500
ICC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity against rat Kv2.2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt Details

UniProt (Human): Q14721
UniProt (Immunogen Species): P15387

Product Specific References for Applications and Species

Electrophysiology: Rat
Immunocytochemistry: Hamster | Human | Mouse | Rat
Immunohistochemistry: Hamster | Human | Mouse | Non-Human Primate | Rat
Immunoprecipitation: Mouse
PLA: Mouse
SDS-FRL: Mouse | Rat
Western Blot: Hamster | Human | Mouse | Rat
Additional Publications: Unspecified

Electrophysiology: Rat
PMID	Dilution	Publication
33854181	0.5 µg/mL	Dallas, M.L., et al. 2021. Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2. 1. Scientific Reports, 8194.

Immunocytochemistry: Hamster
PMID	Dilution	Publication
31682765	not listed	Yu, W., et al. 2019. Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling. The FASEB Journal, 14680-9.

Immunocytochemistry: Human
PMID	Dilution	Publication
30091655	1:5 (supe)	Kirmiz, M., et al. 2018. Remodeling neuronal ER–PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Molecular Neurobiology of the Cell, 2410-32.
26503721	not listed	Thiffault, I., et al. 2015. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.. The Journal of General Physiology, 399-410.

Immunocytochemistry: Mouse
PMID	Dilution	Publication
37507375	10ug/ml	Casas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.
34435615	10 µg/mL	Newkirk, G.S., et al. 2022. Kv2. 1 potassium channels regulate repetitive burst firing in extratelencephalic neocortical pyramidal neurons. Cerebral Cortex, 1055-76.
34280489	1:500	Ding, T., et al. 2021. Kv2.1 expression in giant reticular neurons of the postnatal mouse brain. Journal of Chemical Neuroanatomy, 102005.
31600826	1:2 (supe)	Kang, S.K., et al. 2019. Spectrum of KV2.1 Dysfunction in KCNB1‐Associated Neurodevelopmental Disorders. Annals of Neurology, 899-912.
28065942	1:100	Casanovas, A., et al. 2017. Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury. Scientific Reports, 40155.
20853508	not listed	Hermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.

Immunocytochemistry: Rat
PMID	Dilution	Publication
31594866	10 µg/mL	Kirmiz, M., et al. 2019. Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. Journal of Biological Chemistry, 17735-57.
30667360	1:10 (supe)	Andrews, N.P., et al. 2019. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain. eLife, e43322.
29395909	not listed	Berger, S.L., et al. 2018. Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment. Neuron, 555-570.
26442584	not listed	Cobb, M.M., et al. 2015. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.. The Journal of Biological Chemistry, 29189-201.
20853508	not listed	Hermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.

Immunohistochemistry: Hamster
PMID	Dilution	Publication
31591393	not listed	Yu, W., et al. 2017. Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death & Disease, e2737.
28383553	not listed	Yu, W., et al. 2017. Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death & Disease, e2737.

Immunohistochemistry: Human
PMID	Dilution	Publication
29483285	1:800	Gayet-Primo, J., et al. 2018. Heteromeric KV2/KV8. 2 channels mediate delayed rectifier potassium currents in primate photoreceptors. Journal of Neuroscience, 3414-27.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
38137092	1:100	Li, Q, et al. 2023. Visualization and Characterization of the Brain Regional Heterogeneity of Astrocyte-Astrocyte Structural Interactions by Using Improved Iontophoresis with Dual-Fluorescent Dyes. Brain Sciences, 1644.
37507375	10ug/ml	Casas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.
37323648	1:1000	Biro, L, et al. 2023. Post-weaning Social Isolation in Male Mice Leads to Abnormal Aggression and Disrupted Network Organization in the Prefrontal Cortex: Contribution of Parvalbumin Interneurons With or Without Perineuronal Nets. Neurobiology of Stress, 100546.
36640913	1:500	Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233.
36130488	not listed	Cserép, C., et al. 2022. Microglial Control of Neuronal Development via Somatic Purinergic Junctions. Cell Reports, 111369.
35201268	1:500	Császár, E., et al. 2022. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions. The Journal of experimental medicine, .
34652420	1:1500	Inamdar, S.M., et al. 2022. Differential impact of Kv8. 2 loss on rod and cone signaling and degeneration. Human Molecular Genetics, 1035-50.
34825141	not listed	Buettner, J.M., et al. 2021. Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models. iScience, 103376.
33333928	not listed	Song, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
32937450	1:200	Schulien, A.J., et al. 2020. Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischeemic stroke in mice by declustering Kv2.1 channels. Science Advances, eaaz8110.
32684634	1:1000	Asede, D., et al. 2020. Deletion of NRXN1α impairs long-range and local connectivity in amygdala fear circuit. Translational Pyschiatry, 242.
31987008	1:500	Varga, D.P., et al. 2020. Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain. Journal of Cerebral Blood Flow and Metabolism, S67-80.
31831638	not listed	Cserép, C., et al. 2020. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science, 528-537.
31664163	1:1000	Thiebaud, N., et al. 2019. A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1. Scientific Reports, 15542.
31345270	1:100	Nishino, K., et al. 2019. Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway. Acta Neuropathologica Communications, 118.
30912977	1:100	Salvany, S., et al. 2019. Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair. The FASEB Journal, 7833-51.
30050035	not listed	Wei, Y., et al. 2018. Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer’s disease. Cell Death & Disease, 820.
30012696	1:10 (supe)	Kirmiz, M., et al. 2018. Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum–Plasma Membrane Junctions in Mammalian Brain Neurons. The Journal of Neuroscience, 7562-84.
29954847	1:1000	Rhomberg, T., et al. 2018. Vasoactive Intestinal Polypeptide-Immunoreactive Interneurons within Circuits of the Mouse Basolateral Amygdala. The Journal of Neuroscience, 6983-7003.
29502344	1:1000	Dukkipati, S.S., et al. 2018. The vulnerability of spinal motoneurons and soma size plasticity in a mouse model of amyotrophic lateral sclerosis. The Journal of Physiology, 1723-45.
29403353	not listed	Bishop, H.I., et al. 2018. Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.. Frontiers in Molecular Neuroscience, 1.
28856240	5 µg/mL	Palacio, S., et al. 2017. Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons. eNeuro, ENEURO.0267-17.2017.
28060701	1:1000	Veres, J.M., et al. 2017. Perisomatic GABAergic synapses of basket cells effectively control principal neuron activity in amygdala networks. eLife, e20721.
27798188	1:100	Yu, W., et al. 2016. Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury.. Journal of Neuroscience, 11084-11096.
26891847	1:250	Lasiene, J., et al. 2016. Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.. Acta Neuropathologica Communications, 15.
24962901	1:100	Mandikian, D., et al. 2014. Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors.. Journal of Comparative Neurology, 3555-74.

Immunohistochemistry: Non-Human Primate
PMID	Dilution	Publication
34716617	1:300	Muñoz, Y., et al. 2021. Light microscopic and heterogeneity analysis of astrocytes in the common marmoset brain.. Journal of Neuroscience Research, 3121-3147.

Immunohistochemistry: Rat
PMID	Dilution	Publication
33333928	not listed	Song, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
32726631	not listed	Holderith, N., et al. 2020. A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses. Cell Reports, 107968.
31594866	10 µg/mL	Kirmiz, M., et al. 2019. Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. Journal of Biological Chemistry, 17735-57.
24723263	1:250	Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.
22675541	not listed	Manning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.
20853508	not listed	Hermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.

Immunoprecipitation: Mouse
PMID	Dilution	Publication
30922570	10 µg	Yu, W., et al. 2019. Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. Biochemical and Biophysical Research Communications, 665-9.

PLA: Mouse
PMID	Dilution	Publication
37507375	10ug/ml	Casas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.

SDS-digested freeze fracture replica-labeling: Mouse
PMID	Dilution	Publication
29127366	1:100	Szoboszlay, M., et al. 2017. Objective quantification of nanoscale protein distributions. Scientific Reports, 15240.

SDS-digested freeze fracture replica-labeling: Rat
PMID	Dilution	Publication
29127366	1:100	Szoboszlay, M., et al. 2017. Objective quantification of nanoscale protein distributions. Scientific Reports, 15240.

Western Blot: Hamster
PMID	Dilution	Publication
29264390	1:250	Calhoun, J.D., et al. 2017. Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy. Neurology Genetics, e198.

Western Blot: Human
PMID	Dilution	Publication
34137443	1:1000	Maverick, E.E., et al. 2021. Kv2 channel–AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking. Journal of Cell Science, jcs256339.
32284408	not listed	Möller, L., et al. 2020. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations. PNAS, 9365-76.
29483285	1:800	Gayet-Primo, J., et al. 2018. Heteromeric KV2/KV8. 2 channels mediate delayed rectifier potassium currents in primate photoreceptors. Journal of Neuroscience, 3414-27.
28938641	1:1000	Liu, X., et al. 2017. Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel. Oncotarget, 59345-58.
28432142	not listed	Vullhorst, D., et al. 2017. Structural similarities between neuregulin 1–3 isoforms determine their subcellular distribution and signaling mode in central neurons. Journal of Neuroscience, 5232-5249.
28119464	not listed	Nystoriak, M.A., et al. 2017. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Science Signaling, eaaf9647.
26503721	not listed	Thiffault, I., et al. 2015. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.. The Journal of General Physiology, 399-410.
25164438	1:500	Torkamani, A., et al. 2014. De novo KCNB1 mutations in epileptic encephalopathy.. Annals of Neurology, 529-40.

Western Blot: Mouse
PMID	Dilution	Publication
37507375	4ug/ml	Casas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.
37321992	1:500	Oh, H, et al. 2023. Kv7/KCNQ Potassium Channels in Cortical Hyperexcitability and Juvenile Seizure-related Death in Ank2-mutant Mice. Nature Communications, 3547.
36842733	not listed	Markandeya, Y.S., et al. 2023. Caveolin-3 and Caveolae Regulate Ventricular Repolarization. Journal of Molecular and Cellular Cardiology, 38-49.
33132203	2 ug/mL	Hawkins,N.A., et al. 2021. Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant. Neurobiology of Disease, 105141.
33393091	1:200	Zhou, L., et al. 2020. Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine-induced status epilepticus. Journal of Neuroscience Research, 914-26.
33333928	not listed	Song, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
29265365	not listed	Chao, R.Y., et al. 2018. Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration. Journal of Neurochemistry, 483-97.
28504671	1:5 (supe)	Fletcher, E.V., et al. 2017. Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. Nature Neuroscience, 905-16.
26538660	not listed	Bishop, H.I., et al. 2015. Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.. Journal of Neuroscience, 14922-42.
26027736	not listed	Vullhorst, D., et al. 2015. A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.. Nature Communications, 7222.
25670860	1:2 (supe)	Nieves-Cintrón, M., et al. 2015. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.. The Journal of Biological Chemistry, 7918-29.
24494598	not listed	Speca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408.
20853508	not listed	Hermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.

Western Blot: Rat
PMID	Dilution	Publication
36545239	1:800	Li, X., et al. 2022. Intrathecal Administration of the Fat-mass and Obesity-associated Protein Inhibitor Mitigates Neuropathic Pain in Female Rats. Translational Perioperative and Pain Medicine, 478-487.
33333928	not listed	Song, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
31594866	10 µg/mL	Kirmiz, M., et al. 2019. Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. Journal of Biological Chemistry, 17735-57.
31240601	1:1000	Vullhorst, D., et al. 2019. NMDA receptors regulate neuregulin 2 binding to ER-PM junctions and ectodomain release. . Molecular neurobiology, 8345-8363.
28768770	not listed	Wu, Y., et al. 2017. NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic β-cells. Journal of Biological Chemistry, 15512-24.
28432142	not listed	Vullhorst, D., et al. 2017. Structural similarities between neuregulin 1–3 isoforms determine their subcellular distribution and signaling mode in central neurons. Journal of Neuroscience, 5232-5249.
22675541	not listed	Manning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.
20853508	not listed	Hermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.

Additional Publications: Unspecified
PMID	Publication
35238051	Colecraft, H.M., et al. 2022. Controlling ion channel function with renewable recombinant antibodies. The Journal of Physiology, 2023-36.
26890139	Frazzini, V., et al. 2016. Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer''s disease mouse model.. Cell Death & Disease, e2100.
26240432	Peltola, M.A., et al. 2016. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.. Schizophrenia Bulletin, 191-201.
26453299	Wu, Y., et al. 2015. Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.. The Journal of Biological Chemistry, 29676-90.
26442584	Cobb, M.M., et al. 2015. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.. The Journal of Biological Chemistry, 29189-201.
26205295	El Gebeily, G., et al. 2015. Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart.. Journal of Molecular and Cellular Cardiology, 85-94.
26115091	He, K., et al. 2015. Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels.. PLoS One, e0129498.
25908859	Fox, P.D., et al. 2015. Induction of stable ER-plasma-membrane junctions by Kv2.1 potassium channels.. Journal of Cell Science, 2096-105.
25568127	Liu, J., et al. 2015. Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.. Journal of Neuroscience, 352-65.
25525262	Ednie, A.R., et al. 2015. Reduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly.. The Journal of Biological Chemistry, 2769-83.
25182224	Jensen, C.S., et al. 2015. Live-cell imaging of post-golgi transport vesicles in cultured hippocampal neurons.. Cell Molecular Neurobiology, 123-35.
25674050	Moutal, A., et al. 2014. Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.. Frontiers in Neuroscience, 471.
25260053	Krasowska, E., et al. 2014. Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy.. PLoS One, e108364.
25220706	Siddoway, B., et al. 2014. Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity.. Neuroscience Letters, 142-7.
24928958	McCord, M.C., et al. 2014. Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents.. The Journal of Physiology, 3511-21.
24723263	Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.
24647953	Shah, N.H., et al. 2014. Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia.. Journal of Neuroscience, 4326-31.
24606584	Kirizs, T., et al. 2014. Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells.. European Journal of Neuroscience, 1771-83.
24597762	Wang, C.Y., et al. 2014. GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells.. Biochemical Journal, 35-47.
24569993	Jensen, C.S., et al. 2014. Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons.. The Journal of Biological Chemistry, 10566-81.
24494598	Speca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408.
24477962	King, A.N., et al. 2014. A unique ion channel clustering domain on the axon initial segment of mammalian neurons.. Journal of Comparative Neurology, 2594-608.
24445605	Hund, T.J., et al. 2014. β(IV)-Spectrin regulates TREK-1 membrane targeting in the heart.. Cardiovascular Research, 166-75.
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Anti-Kv2.1 K+ Channel Antibody

Cat# 75-014-020

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Brand : Antibodies Incorporated

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Anti-Kv2.1 K+ Channel Antibody (K89/34)

SKU: 75-014

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