7-Dehydrocholesterol [434-16-2]
Cat# HY-113279-100mg
Size : 100mg
Brand : MedChemExpress
7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.
For research use only. We do not sell to patients.
7-Dehydrocholesterol Chemical Structure
CAS No. : 434-16-2
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of 7-Dehydrocholesterol:
- 7-Dehydrocholesterol-d7 Get quote
Description |
7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3. |
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IC50 & Target |
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In Vitro |
7-Dehydrocholesterol is a biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is present in relatively high concentration in skin where it is converted to pre-vitamin D3 upon UV irradiation and where it is also exposed to exogenous radical sources and oxygen[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
384.64 |
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Formula |
C27H44O |
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CAS No. |
434-16-2 |
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Appearance |
Solid |
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Color |
White to light yellow |
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SMILES |
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(06)C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3(06)CC[C@]12C |
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Structure Classification |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
Ethanol : 16.67 mg/mL (43.34 mM; Need ultrasonic) DMSO : < 1 mg/mL (insoluble or slightly soluble) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.68% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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Ethanol | 1 mM | 2.5998 mL | 12.9992 mL | 25.9983 mL | 64.9958 mL |
5 mM | 0.5200 mL | 2.5998 mL | 5.1997 mL | 12.9992 mL | |
10 mM | 0.2600 mL | 1.2999 mL | 2.5998 mL | 6.4996 mL | |
15 mM | 0.1733 mL | 0.8666 mL | 1.7332 mL | 4.3331 mL | |
20 mM | 0.1300 mL | 0.6500 mL | 1.2999 mL | 3.2498 mL | |
25 mM | 0.1040 mL | 0.5200 mL | 1.0399 mL | 2.5998 mL | |
30 mM | 0.0867 mL | 0.4333 mL | 0.8666 mL | 2.1665 mL | |
40 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6249 mL |