Human Choline Acetyltransferase (CHAT) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CHAT
Locus ID	1103
Kit Components	GA100785G1, Choline Acetyltransferase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100785G2, Choline Acetyltransferase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100785G3, Choline Acetyltransferase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001142929, NM_001142933, NM_001142934, NM_020549, NM_020984, NM_020985, NM_020986
UniProt ID	P28329
Synonyms	CHOACTASE; CMS1A; CMS1A2
Summary	This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]