Human UDP glucose dehydrogenase (UGDH) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	UGDH
Locus ID	7358
Kit Components	GA105069G1, UDP glucose dehydrogenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105069G2, UDP glucose dehydrogenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105069G3, UDP glucose dehydrogenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001184700, NM_001184701, NM_003359
UniProt ID	O60701
Synonyms	GDH; UDP-GlcDH; UDPGDH; UGD
Summary	The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]