Human Acid Phosphatase 2 (ACP2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ACP2
Locus ID	53
Kit Components	GA100041G1, Acid Phosphatase 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100041G2, Acid Phosphatase 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100041G3, Acid Phosphatase 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001131064, NM_001302489, NM_001302490, NM_001302491, NM_001302492, NM_001610, NM_001357016
UniProt ID	P11117
Synonyms	acid phosphatase 2, lysosomal; Acp-2; LAP; OTTMUSP00000015308
Summary	The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]