General Info
| Host: | Mouse |
| Applications: | WB/IP/IHC/IF |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Protein c-Fos is suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 6A3 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | FOS |
| Gene ID: | 2353 |
| Uniprot ID: | FOS_HUMAN |
| Specificity: | The antibody detects endogenous c-fos protein. |
| Immunogen: | Recombinant Protein of c-Fos |
Description
| Function | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Protein Name | Protein C-FosCellular Oncogene FosFos Proto-Oncogene - Ap-1 Transcription Factor SubunitG0/G1 Switch Regulatory Protein 7Proto-Oncogene C-FosTranscription Factor Ap-1 Subunit C-Fos |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2871796Reactome: R-HSA-450341Reactome: R-HSA-6785807Reactome: R-HSA-6796648Reactome: R-HSA-9018519Reactome: R-HSA-9031628Reactome: R-HSA-9634638Reactome: R-HSA-9768919 |
| Cellular Localisation | NucleusEndoplasmic ReticulumCytoplasmCytosolIn Quiescent CellsPresent In Very Small Amounts In The CytosolFollowing Induction Of Cell GrowthFirst Localizes To The Endoplasmic Reticulum And Only Later To The NucleusLocalization At The Endoplasmic Reticulum Requires Dephosphorylation At Tyr-10 And Tyr-30 |
| Alternative Antibody Names | Anti-Protein C-Fos antibodyAnti-Cellular Oncogene Fos antibodyAnti-Fos Proto-Oncogene - Ap-1 Transcription Factor Subunit antibodyAnti-G0/G1 Switch Regulatory Protein 7 antibodyAnti-Proto-Oncogene C-Fos antibodyAnti-Transcription Factor Ap-1 Subunit C-Fos antibodyAnti-FOS antibodyAnti-G0S7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance