General Info
Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phospho-Insulin receptor substrate 1-Ser636 (603-652 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | IRS1 |
Gene ID: | 3667 |
Uniprot ID: | IRS1_HUMAN |
Immunogen Region: | 603-652 aa |
Specificity: | Phospho-IRS-1 (S636) Polyclonal Antibody detects endogenous levels of IRS-1 protein only when phosphorylated at S636. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human IRS-1 around the phosphorylation site of Ser636 at the amino acid range 603-652 |
Description
Function | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. |
Protein Name | Insulin Receptor Substrate 1Irs-1 |
Database Links | Reactome: R-HSA-109704Reactome: R-HSA-112399Reactome: R-HSA-112412Reactome: R-HSA-1257604Reactome: R-HSA-1266695Reactome: R-HSA-198203Reactome: R-HSA-201556Reactome: R-HSA-2219530Reactome: R-HSA-2428928Reactome: R-HSA-2586552Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-74713Reactome: R-HSA-74749Reactome: R-HSA-9603381Reactome: R-HSA-9725370Reactome: R-HSA-982772 |
Alternative Antibody Names | Anti-Insulin Receptor Substrate 1 antibodyAnti-Irs-1 antibodyAnti-IRS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance