Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	LRP1
Gene ID:	4035
Uniprot ID:	LRP1_HUMAN
Immunogen Region:	4486-4535 aa
Specificity:	LRP1 Polyclonal Antibody detects endogenous levels of LRP1 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human CD91 at the amino acid range 4486-4535

Post Translational Modifications	Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Function	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Protein Name	Prolow-Density Lipoprotein Receptor-Related Protein 1 Lrp-1 Alpha-2-Macroglobulin Receptor A2mr Apolipoprotein E Receptor Apoer Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain Lrpicd
Database Links	Reactome: R-HSA-2168880 Reactome: R-HSA-975634
Cellular Localisation	Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell Membrane Single-Pass Type I Membrane Protein Membrane Coated Pit Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell Membrane Peripheral Membrane Protein Extracellular Side Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: Cytoplasm Nucleus After Cleavage The Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The Nucleus Golgi Outpost Cytoplasm Cytoskeleton Microtubule Organizing Center Localizes To The Postsynaptic Golgi Apparatus Region Also Named Golgi Outpost Which Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation
Alternative Antibody Names	Anti-Prolow-Density Lipoprotein Receptor-Related Protein 1 antibody Anti-Lrp-1 antibody Anti-Alpha-2-Macroglobulin Receptor antibody Anti-A2mr antibody Anti-Apolipoprotein E Receptor antibody Anti-Apoer antibody Anti-Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit antibody Anti-Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit antibody Anti-Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain antibody Anti-Lrpicd antibody Anti-LRP1 antibody Anti-A2MR antibody Anti-APR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance