A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7) BioAssay™ ELISA Kit (Rat)

Katalog-Nummer 023067-96T

Size : 96Tests

Marke : US Biological

Contact local distributor :


Telefonnummer : +1 850 650 7790


Shipping Temp
Blue Ice

Storage Temp
4°C/-20°C

ADAMTS7, A disintegrin and metalloproteinase with thrombospondin motifs 7, ADAM-TS 7, ADAM-TS7, ADAMTS-7, COMPase
ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including lung, kidney and liver. ADAMTS-7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7), also known as COMPase, is a 1686aa protein that exists as two alternatively spliced isoforms. Encoded by a gene that maps to human chromosome 15q25.1, ADAMTS-7 contains eight TSP-1 motifs and binds one zinc ion per subunit. ADAMTS-7 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. ADAMTS-7 is also located in meniscus, bone, tendon, cartilage, synovium, fat and ligaments, and is up-regulated in articular cartilage and synovium in arthritis patients. ADAMTS-7 functions as a metalloprotease and may play a role in the degradation of COMP. ADAMTS-7 is pH dependent, with optimum pH between 7.5 and 9.5.

A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7) BioAssay™ ELISA Kit (Rat) is a sandwich enzyme immunoassay for the in vitro quantitative measurement of ADAMTS7 in rat serum, plasma and other biological fluids.

Detection Range:
0.156-10ng/ml

Sensitivity:
0.058ng/ml

Storage and Stability:
Desiccation recommended. The Standard, Detection Reagent A, Detection Reagent B and the 96-well strip plate should be stored at -20°C upon receipt. Store all other reagents at 4°C. Stable for 6 months after receipt of order.

Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.