Mmp14 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN310167LP
Mmp14 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
| Donor DNA | Luciferase-Puro |
| Symbol | Mmp14 |
| Locus ID | 17387 |
| Components | KN310167G1, Mmp14 gRNA vector 1 in pCas-Guide CRISPR vector KN310167G2, Mmp14 gRNA vector 2 in pCas-Guide CRISPR vector KN310167LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_008608 |
| UniProt ID | P53690 |
| Synonyms | AI325305; MMP-X1; MT-MMP-1; MT1-MMP; sabe |
| Summary | This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016] |
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN310167 | Mmp14 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN310167BN | Mmp14 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN310167RB | Mmp14 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN510167 | Mmp14 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA202678 | Mmp14 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 14 (membrane-inserted) | 1 657,00 EUR |