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> Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone [634911-81-2]

Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone [634911-81-2]

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Katalog-Nummer 4027403.0001

Size : 1mg

Marke : Bachem

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SequenceZ-Val-Ala-DL-Asp(OMe)-fluoromethylketone
Salt
Binding
SynonymZ-VAD(OMe)-FMK, Caspase-1 Inhibitor V
SumFormulaC₂₂H₃₀FN₃O₇
CASNumber634911-81-2
MW467,5
StorageTemp< -15°C
Size1mg
Shipment ConditionAmbient Temperature

Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone

Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone

Product Number: 4027403

CAS Number: 634911-81-2

€ 107 – € 428

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Product Description

Z-VAD(OMe)-FMK, a pan-caspase inhibitor, is a competitive irreversible peptide inhibitor and blocks caspase-1 family and caspase-3 family enzymes. The methyl ester of Z-VAD-FMK has been used in studies to support the hypothesis that inhibitors of caspases can limit brain infarction resulting from the permanent obstruction of a brain artery.

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Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus.

A.Kondratyev and K.Gale, Mol. Brain Res., 75, 216 (2000)

Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo.

C.Wiessner et al., Cell. Mol. Biol., 46, 53 (2000)

Effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat.

S.M.Sheen-Chen et al., World J. Gastroenterol., 11, 2330 (2005)

Cytoprotective influence of ZVAD-fmk and glycine on gel-entrapped rat hepatocytes in a bioartificial liver.

S.L.Nyberg et al., Surgery, 127, 447 (2000)

Caspase Inhibition by ZVAD-fmk Reduces Apoptotic Death of Hepatocytes in a Bioartificial Liver.

S.L.Nyberg et al., Surg. Forum, 50, 5 (1999)

Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates.

A.Komoriya et al., J. Exp. Med., 191, 1819 (2000)

B.K.Garvalov et al., J. Neurosci., 27, 13117 (2007)

Molecular weight: 467.5

Sum Formula: C₂₂H₃₀FN₃O₇

Storage Temperature: < -15°C

Synonyms: Z-VAD(OMe)-FMK

One Letter code: Z-VAD(OMe)-FMK

Source: Synthetic

Old Product Number: N-1560

Inhibitors
"Caspase-1 (ICE)
Caspase-3 (CPP-32; Yama; Apopain)"

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