WWTR1 Antibody - N-terminal region : Biotin
Katalog-Nummer ARP32540_P050-Biotin
Size : 100ul
Marke : Aviva Systems Biology
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Telefonnummer : +1 850 650 7790
WWTR1 Antibody - N-terminal region : Biotin (ARP32540_P050-Biotin)
| Datasheets/Manuals | Printable datasheet for anti-WWTR1 (ARP32540_P050-Biotin) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit |
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| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | Biotin |
| Application | WB |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human WWTR1 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: PRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDVTDELP |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-WWTR1 (ARP32540_P050-Biotin) antibody is Catalog # AAP32540 (Previous Catalog # AAPP35146) |
| Reference | Hong, J., et al., (2005) Science, 309(5737),1074-1078 |
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| Gene Symbol | WWTR1 |
| Gene Full Name | WW domain containing transcription regulator 1 |
| Alias Symbols | TAZ |
| NCBI Gene Id | 25937 |
| Protein Name | WW domain-containing transcription regulator protein 1 |
| Description of Target | TAZ (transctiptional coactivator with PDZ-binding motif), also known as WW domain containing transcription regulator 1 (WWTR1), is a member of the bicoid sub-family of homeodomain-containing transcription factors. TAZ is a 14-3-3 binding protein that co-activates Runx2-dependent gene transcription while repressing PPAR-gamma-dependent gene transcription. TAZ has been reported to be a modulator of mesenchymal stem cell differentiation. TAZ may also play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. |
| Uniprot ID | Q9GZV5 |
| Protein Accession # | NP_056287 |
| Nucleotide Accession # | NM_015472 |
| Protein Size (# AA) | 400 |
| Molecular Weight | 44kDa |
| Protein Interactions | MED28; NOTCH1; YWHAQ; LATS1; BTRC; YWHAE; TP53BP2; PPP1CA; KLF5; YWHAZ; YWHAG; PAX3; SLC9A3R2; TEAD3; TEAD4; NKX2-1; RUNX1; |
