B3679-200mg | Vanillin [121-33-5] Biotrend

Background

Vanillin is the primary chemical component in the extract of vanilla bean, which has been widely used as a flavorant in foods, beverages and tobacco due to its popular odor. Vanillin has multifunctional effects such as anti-sickling, antiangiogenetic, anti-colitis, antianalgesic and antioxidant effects. Thus, vanillin might be used as a potential agent for the treatment of sickle cell anemia and major depressive disorder, as well as an antagonizing compound to counteract the negative effects of ultraviolet A (UVA) irradiation on proliferative potential and stemness of human adipose tissue-derived mesenchymal stem cells (hAMSCs).

References:

1. Abraham DJ, Mehanna AS, Wireko FC, et al. Vanillin, a potential agent for the treatment of sickle cell anemia. Blood, 1991, 77(6): 1334-1341.

2. Lee SY, Park SH, Kim MO, et al. Vanillin attenuates negative effects of ultraviolet A on the stemness of human adipose tissue-derived mesenchymal stem cells. Food and Chemical Toxicology, 2016, 96: 62-69.

3. Xu J, Xu H, Liu Y, et al. Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain. Psychiatry Research, 2015, 225(3): 509-514.

Chemical Properties

Storage	Store at -20°C
M.Wt	152.15
Cas No.	121-33-5
Formula	C₈H₈O₃
Solubility	insoluble in H2O; ≥31.1 mg/mL in DMSO; ≥41.3 mg/mL in EtOH
SDF	Download SDF
Canonical SMILES	OC1=C(C=C(C=O)C=C1)OC
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[2]
Cell lines	hAMSCs
Reaction Conditions	1 ~ 100 μM vanillin for 3 d incubation
Applications	Vanillin dose-dependently attenuated UVA-induced reduction of the proliferative potential and stemness of hAMSCs. At the tested concentrations, vanillin exhibited no apoptotic effects. In addition, the reduced expression levels of OCT4, NANOG and SOX2 caused by UVA irradiation were all increased by vanillin treatment.
Animal experiment:[3]
Animal models	A rat model of chronic depression
Dosage form	5ml of 600 mg/l vanillin (in distilled water) Sprayed on to the floor, at 8 hourly intervals
Applications	Vanillin could alleviate depressive symptoms in the rat model of chronic depression via the olfactory pathway. Moreover, vanillin elevated both serotonin and dopamine levels in brain tissue.
Note	The technical data provided above is for reference only.
	References: 1. Abraham DJ, Mehanna AS, Wireko FC, et al. Vanillin, a potential agent for the treatment of sickle cell anemia. Blood, 1991, 77(6): 1334-1341. 2. Lee SY, Park SH, Kim MO, et al. Vanillin attenuates negative effects of ultraviolet A on the stemness of human adipose tissue-derived mesenchymal stem cells. Food and Chemical Toxicology, 2016, 96: 62-69. 3. Xu J, Xu H, Liu Y, et al. Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain. Psychiatry Research, 2015, 225(3): 509-514.

Quality Control

Purity = 99.98%

Chemical structure

Vanillin [121-33-5]

Katalog-Nummer B3679-200mg

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Marke : ApexBio Technology