TrkA Inhibitor [388626-12-8]

Katalog-Nummer VD-OEIA-10008-1mg

Size : 1mg

Marke : VDM Biochemicals

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Telefonnummer : +1 850 650 7790

Product Specification

  • Appearance
    :

    Yellow solid

  • CAS Number
    :

    388626-12-8

  • Cat.number
    :

    VD-OEIA-10008

  • Formula
    :

    C15H13N3O3S

  • MW
    :

    315.4

  • Purity
    :

    ≥97% (sum of two isomers)

  • Solubility
    :

    DMSO

  • Storage
    :

    +2°C to +8°C. Protect from light.

  • Synonyms
    :

    (Z)-4-(((2-oxoindolin-3-ylidene)methyl)amino)benzenesulfonamide

  • Size
    :

    1mg, 5mg

SKU: VD-OEIA-10008 Categories: Enzyme Inhibitors, Other Enzyme Inhibitors and Activators

Description

An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

1.Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.