Biotrend > THY1 Antibody
THY1 Antibody
Katalog-Nummer OAEE01008
Size : 100tests(T100)
Marke : Aviva Systems Biology
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Datasheets/Manuals | Printable datasheet for THY1 Antibody |
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Predicted Species Reactivity | Dog|Horse|Human|Non-human Primate|Porcine |
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Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Clonality | Monoclonal |
Clone | 5E10 |
Isotype | IgG1 |
Host | Mouse |
Conjugation | R-PE |
Application | FC |
Reconstitution and Storage | 2°C to 8°C |
Immunogen | HEL erythroleukemia cells |
Purification | Purified by size-exclusion chromatography |
Concentration | 10 ul / test |
Specificity | The mouse monoclonal antibody 5E10 recognizes CD90/Thy-1, a GPI-anchored cell surface glycoprotein expressed predominantly on thymocytes, hematopoietic stem cells and neurons. |
Formulation | PE |
Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
Reference | Hoppstädter J, Diesel B, Zarbock R, Breinig T, Monz D, Koch M, Meyerhans A, Gortner L, Lehr CM, Huwer H, Kiemer AK: Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages. Respir Res. 2010 Sep 15;11:124. Kroeze KL, Jurgens WJ, Doulabi BZ, van Milligen FJ, Scheper RJ, Gibbs S: Chemokine-mediated migration of skin-derived stem cells: predominant role for CCL5/RANTES. J Invest Dermatol. 2009 Jun;129(6):1569-81. Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ: DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res. 2007 Feb 1;67(3):1317-25. Chin-Yee IH, Keeney M, Stewart AK, Belch A, Bence-Buckler I, Couban S, Howson-Jan K, Rubinger M, Stewart D, Sutherland R, Paragamian V, Bhatia M, Foley R: Optimising parameters for peripheral blood leukapheresis after r-metHuG-CSF (filgrastim) and r-metHuSCF (ancestim) in patients with multiple myeloma: a temporal analysis of CD34(+) absolute counts and subsets. Bone Marrow Transplant. 2002 Dec;30(12):851-60. St Louis DC, Woodcock JB, Franzoso G, Blair PJ, Carlson LM, Murillo M, Wells MR, Williams AJ, Smoot DS, Kaushal S, Grimes JL, Harlan DM, Chute JP, June CH, Siebenlist U, Lee KP: Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model. J Immunol. 1999 Mar 15;162(6):3237-48. Ito T, Inaba M, Inaba K, Toki J, Sogo S, Iguchi T, Adachi Y, Yamaguchi K, Amakawa R, Valladeau J, Saeland S, Fukuhara S, Ikehara S: A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol. 1999 Aug 1;163(3):1409-19. And many other. Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells. Blood. 2001 May 1;97(9):2741-9. |
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Gene Symbol | THY1 |
Gene Full Name | Thy-1 cell surface antigen |
Alias Symbols | CD90, CDw90, thy-1 antigen, thy-1 membrane glycoprotein, Thy-1 T-cell antigen. |
NCBI Gene Id | 7070 |
Protein Name | Thy-1 membrane glycoprotein |
Description of Target | May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. |
Uniprot ID | P04216 |
Protein Accession # | NP_006279.2 |
Nucleotide Accession # | NM_006288.3 |
Protein interactions
Name | # of Products |
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ATXN7 | 153 |
FYN | 597 |
Gag | 136 |
ITGAM | 151 |
ITGAV | 127 |
ITGB3 | 174 |
LCK | 537 |
THY1 | 49 |
Vif | 72 |
Biological pathways
Name | # of Products |
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Angiogenesis | 366 |
Cell-cell adhesion | 226 |
Cytoskeleton organization | 135 |
Focal adhesion assembly | 64 |
Negative regulation of axonogenesis | 48 |
Negative regulation of cell migration | 90 |
Negative regulation of protein kinase activity | 216 |
Negative regulation of T cell receptor signaling pathway | 39 |
Positive regulation of release of sequestered calcium ion into cytosol | 61 |
Positive regulation of T cell activation | 121 |
Retinal cone cell development | 30 |
T cell receptor signaling pathway | 453 |
Biological process
Name | # of Products |
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Angiogenesis | 196 |
Cell-cell adhesion | 77 |
Cytoskeleton organization | 97 |
Focal adhesion assembly | 17 |
Negative regulation of axonogenesis | 16 |
Negative regulation of cell migration | 63 |
Negative regulation of protein kinase activity | 53 |
Negative regulation of T cell receptor signaling pathway | 12 |
Positive regulation of GTPase activity | 88 |
Positive regulation of release of sequestered calcium ion into cytosol | 20 |
Positive regulation of Rho GTPase activity | 25 |
Positive regulation of T cell activation | 28 |
Retinal cone cell development | 7 |
T cell receptor signaling pathway | 90 |
Cellular components
Name | # of Products |
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Anchored to external side of plasma membrane | 12 |
Cytosol | 1868 |
Dendrite | 187 |
Endoplasmic reticulum | 837 |
External side of plasma membrane | 261 |
Growth cone | 66 |
Integral to plasma membrane | 817 |
Membrane raft | 140 |
Plasma membrane | 2678 |
Protein function
Name | # of Products |
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Enzyme binding | 898 |
GPI anchor binding | 35 |
Integrin binding | 463 |
Protein binding | 12191 |
Protein kinase binding | 1101 |
Rho GTPase activator activity | 71 |
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