TFRC Antibody - N-terminal region
Katalog-Nummer OASG01347
Size : 100ul
Marke : Aviva Systems Biology
Contact local distributor :
Telefonnummer : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for anti-TFRC (OASG01347) antibody |
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| Predicted Species Reactivity | Human |
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| Product Format | Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Application | WB, IHC-P, ELISA |
| Additional Information | Cellular Localization: Cell membrane Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Transferrin receptor protein 1, serum form: Secreted. |
| Reconstitution and Storage | Store at -20°C. Avoid repeated freeze/thaw cycles. |
| Immunogen | Synthesized peptide derived between 91-140 amino acids from the N-terminal region of human CD71. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Target Post-Translational Modification | N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).; Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. |
| Specificity | CD71 Polyclonal Antibody detects endogenous levels of CD71 protein. |
| Intended Use | For research use only. |
| Application Info | WB: 1:500~2000 IHC-P: 1:100~300 ELISA: 1:20000 Optimal dilutions should be determined by the end user. |
| Gene Symbol | TFRC |
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| Gene Full Name | transferrin receptor |
| Alias Symbols | T9, TR, TFR, p90, CD71, TFR1, TRFR, IMD46 |
| NCBI Gene Id | 7037 |
| Description of Target | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| Uniprot ID | P02786 |
| Molecular Weight | 85 kDa |
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What is the species homology for "TFRC Antibody - N-terminal region (OASG01347)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "TFRC Antibody - N-terminal region (OASG01347)"?
This item is available "Domestic: within 2-3 weeks delivery | International: 2-3 weeks".
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What buffer format is "TFRC Antibody - N-terminal region (OASG01347)" provided in?
This item is provided in "Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TFRC Antibody - N-terminal region (OASG01347)"?
This target may also be called "T9, TR, TFR, p90, CD71, TFR1, TRFR, IMD46" in publications.
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What is the shipping cost for "TFRC Antibody - N-terminal region (OASG01347)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
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What is the guarantee for "TFRC Antibody - N-terminal region (OASG01347)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TFRC Antibody - N-terminal region (OASG01347)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "85 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TFRC Antibody - N-terminal region (OASG01347)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TFRC"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TFRC"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TFRC"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TFRC"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TFRC"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TFRC"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.