Tau, phosphorylated (Thr175)

Tauopathies are a group of diverse dementias and movement disorders which have a common pathological feature in that they all display the presence of intracellular accumulation of abnormal filaments of tau protein. Furthermore, these accumulated tau proteins all display an abnormal phosphorylation pattern that may be disease specific. As an example, Amyotrophic lateral sclerosis (ALS, also referred to as Charcot’s disease or Lou Gehrig’s disease) is the most common form of progressive motor neuron disease in North America. ALS gradually disables the patient’s voluntary motor muscle control until it becomes fatal.

Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Western Blot: 1:10,000
Immunohistochemistry: 1:1000
Optimal dilutions to be determined by the researcher.

Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Pab

IgG

rabbit

human

~1mg/ml (after reconstitution)

Supplied as a lyophilized powder in PBS, pH 7.4. No preservative added. Reconstitute with 50ul sterile ddH2O.

Purified by immunoaffinity chromatography.

Synthetic peptide corresponding to human Tau phosphorylated at Thr175.

Recognizes human Tau at Thr 175 phosphorylation site.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.