Sodium Channel Protein Type 8 subunit alpha (Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6, SCN8A, MED)
Katalog-Nummer S5400-100ug
Size : 100ug
Marke : US Biological
Host
mouseIsotype
IgG2a,kClone Number
9G446Grade
Affinity PurifiedApplications
E IF WBShipping Temp
Blue IceStorage Temp
-20°CSodium channel protein type 8 subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes. Adopting opened or closed conformation in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na ions may pass in accordance with their electrochemical gradient. It is a multi-pass transmembrane protein that is widely expressed in neurons of the central and peripheral nervous system. There are four named isoforms. The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment, S4. Segments S4 are thought to be the voltage-sensors and are characterised by a series of positively charged amino acids at every third position.
Applications:
Suitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested.
Recommended Dilutions:
Immunofluorescence: 10ug/ml
Optimal dilutions to be determined by the researcher.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Product Type
Mab
Isotype
IgG2a,k
Clone No
9G446
Host
mouse
Source
human
Concentration
~1mg/ml (after reconstitution)
Form
Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
Purity
Purified by Protein G affinity chromatography.
Immunogen
Partial recombinant human Sodium channel protein type 8 subunit alpha (aa1854-1951) with a GST tag.
Specificity
Recognizes human sodium channel protein. Species Crossreactivity
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.