Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sarcosine [107-97-1]
Katalog-Nummer T6975-100mg
Size : 100mg
Marke : TargetMol
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Sarcosine
Catalog No. T6975 CAS 107-97-1
Synonyms: Sarcosinic acid, Methylaminoacetic acid, Sarcosin, Methylglycine, N-Methylaminoacetic acid, N-methylglycine
Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
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Sarcosine, CAS 107-97-1
| Description | Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. |
| In vitro | Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4]. |
| In vivo | Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3]. |
| Cell Research | Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference) |
| Synonyms | Sarcosinic acid, Methylaminoacetic acid, Sarcosin, Methylglycine, N-Methylaminoacetic acid, N-methylglycine |
| Molecular Weight | 89.09 |
| Formula | C3H7NO2 |
| CAS No. | 107-97-1 |
Storage
Solubility Information
DMSO: Insoluble
H2O: 10 mM
References and Literature
1. Zhang HX, et al. Neuropharmacology. 57(5-6):551-5. 2. Socała K, et al. Pharmacol Rep. 2010, 62(2):392-7. 3. Chen HH, et al. Psychopharmacology (Berl). 2010, 209(4):343-50. 4. Sudhakaran P R , Binu S , Soumya S J . Effect of sarcosine on endothelial function relevant to angiogenesis.[J]. Journal of Cancer Research & Therapeutics, 2014, 10(3):603-610.