Nexturastat A [1403783-31-2]
Katalog-Nummer HY-16699-10mg
Size : 10mg
Marke : MedChemExpress
Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Nexturastat A Chemische Struktur
CAS. Nr. : 1403783-31-2
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- •Cell Death Dis. 2022 Aug 17;13(8):717. [Abstract]
- •Patent. US20180263995A1.
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Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM). | |||||||||||||||||||||||||||||||||
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In Vitro | Nexturastat A (5 g) has inhibitory for HDAC6 with IC50 values of 0.005 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis
Cell Viability Assay
Apoptosis Analysis
RT-PCR
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In Vivo | Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||||||||||||||||||
341.40 | |||||||||||||||||||||||||||||||||
Solid | |||||||||||||||||||||||||||||||||
C19H23N3O3 | |||||||||||||||||||||||||||||||||
1403783-31-2 | |||||||||||||||||||||||||||||||||
O=C(NO)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1 | |||||||||||||||||||||||||||||||||
Room temperature in continental US; may vary elsewhere. | |||||||||||||||||||||||||||||||||
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In Vitro: DMSO : ≥ 56 mg/mL (164.03 mM) *"≥" means soluble, but saturation unknown. Preparing Stock Solutions
*Please refer to the solubility information to select the appropriate solvent. In Vivo:
*All of the co-solvents are available by MCE. | |||||||||||||||||||||||||||||||||
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[1]. Bergman JA, et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9.
[2]. Xiaoyang Sun, et al. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Biosci Rep. 2019 Mar 22;39(3):BSR20181916.
- Cell Cycle/DNA Damage Epigenetics
- HDAC
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.