Neurogenin3, CT (Neurogenin-3, Protein atonal homolog 5, NEUROG3, ATOH5, NGN3)

Neurogenin-3 belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm. Neurogenin-3 also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of congenital malabsorptive diarrhea 4 (DIAR4). DIAR4 is an autosomal recessive disorder characterized by generalized malabsorption and a paucity of enteroendocrine cells.

Suitable for use in Immunohistochemistry and ELISA. Other applications not tested.

Immunohistochemistry (FFPE): 1:50-1:100
Optimal dilutions to be determined by the researcher.

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Pab

IgG

rabbit

human

As Reported

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide

Purified by ammonium sulfate precipitation

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 169-199 in the C-terminal region of human Neurogenin3

Recognizes human Neurogenin3

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.