Mouse SGPL1 (Sphingosine 1 Phosphate Lyase 1) Sandwich ELISA Kit Ready-To-Use E0018527)

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Sgpl1
Gene ID:	20397
Uniprot ID:	SGPL1_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Highest levels are found in liver, small intestine and thymus, followed by kidney, lung, heart, spleen and brain (at protein level). Also detected in stomach, testis and skeletal muscle (at protein level).
Post Translational Modifications
Function	Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.
Protein Name	Sphingosine-1-Phosphate Lyase 1 S1pl Sp-Lyase 1 Spl 1 Mspl Sphingosine-1-Phosphate Aldolase
Database Links	Reactome: R-MMU-1660661
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Iii Membrane Protein Cytoplasmic Side
Alternative ELISA Names	Sphingosine-1-Phosphate Lyase 1 ELISA kit S1pl ELISA kit Sp-Lyase 1 ELISA kit Spl 1 ELISA kit Mspl ELISA kit Sphingosine-1-Phosphate Aldolase ELISA kit Sgpl1 ELISA kit Spl ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance