Mouse ATP6AP2 (ATPase, H+ Transporting, Lysosomal Accessory Protein 2) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Atp6ap2
Gene ID:	70495
Uniprot ID:	RENR_MOUSE
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in glutamatergic and GABAergic neurons with highest levels in the cortex, the hippocampus, the medial habenular nucleus, the cerebellum, the medulla and the olfactory bulb (at protein level).
Post Translational Modifications	Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.
Function	Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
Protein Name	Renin Receptor Atpase H(+-Transporting Lysosomal Accessory Protein 2 Atpase H(+-Transporting Lysosomal-Interacting Protein 2 Renin/Prorenin Receptor Cleaved Into - Renin Receptor Extracellular Fragment - Renin Receptor Cytoplasmic Fragment
Database Links	Reactome: R-MMU-2022377 Reactome: -MMU-6798695
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Lysosome Membrane Cytoplasmic Vesicle Autophagosome Membrane Cell Projection Dendritic Spine Membrane Axon Endosome Membrane Clathrin-Coated Vesicle Membrane Secretory Vesicle Synaptic Vesicle Membrane
Alternative ELISA Names	Renin Receptor ELISA kit Atpase H(+-Transporting Lysosomal Accessory Protein 2 ELISA kit Atpase H(+-Transporting Lysosomal-Interacting Protein 2 ELISA kit Renin/Prorenin Receptor Cleaved Into - Renin Receptor Extracellular Fragment - Renin Receptor Cytoplasmic Fragment ELISA kit Atp6ap2 ELISA kit Atp6ip2 ELISA kit
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Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance