Mouse ATP2B2 (ATPase, Ca++ Transporting, Plasma Membrane 2) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Atp2b2
Gene ID:	11941
Uniprot ID:	AT2B2_MOUSE
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in the retina, with strongest levels in the inner plexiform layer, weaker levels in the outer plexiform layer, and very low levels in the proximal inner nuclear layer. Specifically expressed in the following retinal cell types: rod bipolar cells, horizontal cells, amacrine cells and ganglion cells. Also found in the cochlea (at protein level). Strongly expressed in brain cortex and cerebellum. Found at low levels in heart, liver, lung and testis during late gestation. Expressed in lactating mammary gland (at protein level).
Post Translational Modifications
Function	ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk.
Protein Name	Plasma Membrane Calcium-Transporting Atpase 2 Pmca2 Plasma Membrane Calcium Atpase Isoform 2 Plasma Membrane Calcium Pump Isoform 2
Database Links	Reactome: R-MMU-418359 Reactome: -MMU-5578775 Reactome: -MMU-936837
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Basolateral Cell Membrane Synapse
Alternative ELISA Names	Plasma Membrane Calcium-Transporting Atpase 2 ELISA kit Pmca2 ELISA kit Plasma Membrane Calcium Atpase Isoform 2 ELISA kit Plasma Membrane Calcium Pump Isoform 2 ELISA kit Atp2b2 ELISA kit Pmca2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance