store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lysophosphatidylcholines [9008-30-4]
Katalog-Nummer T36013-50mg
Size : 50mg
Marke : TargetMol
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Lysophosphatidylcholines
Catalog No. T36013 CAS 9008-30-4
Synonyms: Lyso-Lecithins (egg)
Lysophosphatidylcholines (Lyso-Lecithins (egg)) are orally active lipids that induce cell damage and apoptosis, and induce demyelination. Lysophosphatidylcholines play a role in mediating inflammation, fibrosis, and cancer, and can be used to study atherosclerosis.
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Lysophosphatidylcholines, CAS 9008-30-4
| Description | Lysophosphatidylcholines (Lyso-Lecithins (egg)) are orally active lipids that induce cell damage and apoptosis, and induce demyelination. Lysophosphatidylcholines play a role in mediating inflammation, fibrosis, and cancer, and can be used to study atherosclerosis. |
| In vitro | Lysophosphatidylcholines (3 μM, 10 μM, 30 μM, 100 μM; 24 hours) reduced HUVEC viability in a concentration-dependent manner[1]. |
| In vivo | Lysophosphatidylcholines (0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg; oral) significantly protected albino ICR mice against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg[4]. |
| Synonyms | Lyso-Lecithins (egg) |
| Molecular Weight | 495.6 |
| Formula | C24H50NO7P (for palmitoyl) |
| CAS No. | 9008-30-4 |
Storage
Solubility Information
Chloroform:Methanol(2:1): Soluble
DMSO: < 0.1 mg/mL (insoluble or slightly soluble)
H2O: < 0.1 mg/mL (insoluble.)
Methanol: 15 mg/mL, Sonication is recommended.
References and Literature
1. Kim E A, et al. Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress [J]. The Journal of Maternal-Fetal & Neonatal Medicine, 2009, 22(4): 325-331. 2. Liu-Wu Y, et al. Lysophosphatidylcholine induces the production of IL-1β by human monocytes [J]. Atherosclerosis, 1998, 137(2): 351-357. 3. Takahashi M, et al. Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism [J]. Atherosclerosis, 2002, 161(2): 387-394. 4. Yan J J, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis [J]. Nature medicine, 2004, 10(2): 161-167.
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Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
Lysophosphatidylcholines 9008-30-4 Apoptosis Lyso-Lecithins (egg) egg Lyso-Lecithins inhibitor inhibit