LFA3 (CD58) Mouse Monoclonal Antibody [Clone ID: MEM-63]

Specifications

Product Data
Clone Name	MEM-63
Applications	FC
Recommended Dilution	Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivities	Human, Porcine
Host	Mouse
Isotype	IgG1
Clonality	Monoclonal
Immunogen	NALM-6 human pre-B cell line
Specificity	This antibody reacts with CD58 (LFA-3), a 40-70 kDa glycoprotein distributed over many tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts.
Formulation	Tris buffered saline (TBS) solution containing 15 mM sodium azide Label: APC State: Liquid purified Ig fraction Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation	APC
Storage	Store undiluted at 2-8°C. DO NOT FREEZE! This products is photosensitive and should be protected from light.
Stability	Shelf life: one year from despatch.
Database Link	Entrez Gene 965 Human UniProt ID P19256
Background	CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B.
Synonyms	Ag3, LFA-3
Reference Data