Human S1PR1 (Sphingosine 1 Phosphate Receptor 1) Sandwich ELISA Kit Ready-To-Use E0018386)

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	S1PR1
Gene ID:	1901
Uniprot ID:	S1PR1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Post Translational Modifications	S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling.
Function	G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Protein Name	Sphingosine 1-Phosphate Receptor 1 S1p Receptor 1 S1p1 Endothelial Differentiation G-Protein Coupled Receptor 1 Sphingosine 1-Phosphate Receptor Edg-1 S1p Receptor Edg-1 Cd Antigen Cd363
Database Links	Reactome: R-HSA-419408 Reactome: R-HSA-6785807 Reactome: R-HSA-9679191
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Endosome Membrane Raft Recruited To Caveolin-Enriched Plasma Membrane Microdomains In Response To Oxidized 1-Palmitoyl-2-Arachidonoyl-Sn-Glycero-3-Phosphocholine Ligand Binding Leads To Receptor Internalization
Alternative ELISA Names	Sphingosine 1-Phosphate Receptor 1 ELISA kit S1p Receptor 1 ELISA kit S1p1 ELISA kit Endothelial Differentiation G-Protein Coupled Receptor 1 ELISA kit Sphingosine 1-Phosphate Receptor Edg-1 ELISA kit S1p Receptor Edg-1 ELISA kit Cd Antigen Cd363 ELISA kit S1PR1 ELISA kit CHEDG1 ELISA kit EDG1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance