Human CIRBP (Cold-Inducible RNA-Binding Protein) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	CIRBP
Gene ID:	1153
Uniprot ID:	CIRBP_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs. Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.
Function	Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
Protein Name	Cold-Inducible Rna-Binding Protein A18 Hnrnp Glycine-Rich Rna-Binding Protein Cirp
Database Links
Cellular Localisation	Nucleus Nucleoplasm Cytoplasm Translocates From The Nucleus To The Cytoplasm After Exposure To Uv Radiation Translocates From The Nucleus To The Cytoplasm Into Stress Granules Upon Various Cytoplasmic Stresses Such As Osmotic And Heat Shocks Its Recruitment Into Stress Granules Occurs In The Absence Of Tiar Proteins
Alternative ELISA Names	Cold-Inducible Rna-Binding Protein ELISA kit A18 Hnrnp ELISA kit Glycine-Rich Rna-Binding Protein Cirp ELISA kit CIRBP ELISA kit A18HNRNP ELISA kit CIRP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance