Human CD54C Antibody : APC
Katalog-Nummer OASB02585
Size : 100tests
Marke : Aviva Systems Biology
Contact local distributor :
Telefonnummer : +1 850 650 7790
Human CD54C Antibody : APC (OASB02585)
| Datasheets/Manuals | Printable datasheet for Human CD54C Antibody : APC (OASB02585) |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugation | APC |
| Application | FC |
| Additional Information | Description: CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of CD54 are CD11a/LFA-1alpha and CD11b/Mac-1alpha. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation presumably by enhancing interactions between T cells and APC. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Rheumatoid synovial cells and human monocytes |
| Concentration | Lot specific |
| Specificity | CD54 |
| Gene Symbol | ICAM1, ICAM1 |
|---|---|
| Gene Full Name | intercellular adhesion molecule 1 |
| Alias Symbols | BB2, CD54, P3.58 |
| NCBI Gene Id | 3383; 396750 |
| Protein Name | intercellular adhesion molecule 1 |
| Description of Target | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. |
| Uniprot ID | P05362, Q9MZU5 |
| Protein Accession # | NP_000192.2 |
| Nucleotide Accession # | NM_000201.2 |
