GSK-3 Inhibitor X [740841-15-0]

Katalog-Nummer VD-OEIA-0016-1mg

Size : 1mg

Marke : VDM Biochemicals

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Telefonnummer : +1 850 650 7790

Product Specification

  • Appearance
    :

    Dark purple solid

  • CAS Number
    :

    740841-15-0

  • Cat.number
    :

    VD-OEIA-0016

  • Formula
    :

    C18H12BrN3O3

  • MW
    :

    398.2

  • Purity
    :

    ≥97%

  • Solubility
    :

    DMSO

  • Storage
    :

    +2°C to +8°C. Protect from light.

  • Synonyms
    :

    BIO-Acetoxime

  • Size
    :

    1mg, 5mg

SKU: VD-OEIA-0016 Categories: Enzyme Inhibitors, Other Enzyme Inhibitors and Activators

Description

An acetoxime analog of BIO, GSK-3 Inhibitor IX that exhibits greater selectivity for GSK-3α/β (IC50=10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50=2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50≥10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50=0.16 µM) reporter systems.

1.Knockaert, M., et al. 2004. Oncogene 23, 4400.
2.Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
3.Meijer, L., et al. 2003. Chem. Biol. 10, 1255.