Description
An acetoxime analog of BIO, GSK-3 Inhibitor IX that exhibits greater selectivity for GSK-3α/β (IC50=10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50=2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50≥10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50=0.16 µM) reporter systems.