Specifications

Product Data
Applications	IHC
Recommended Dilution	IHC: 25-100 Positive control: Human cervical cancer Predicted cell location: Cytoplasm
Reactivities	Human
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1215-1229 amino acids of human filaggrin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Gene Name	filaggrin
Database Link	NP_002007 Entrez Gene 2312 Human UniProt ID P20930
Background	The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor; profilaggrin (consisting of multiple filaggrin units of 324 aa each); which is localized in keratohyalin granules; and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
Synonyms	ATOD2
Reference Data
Protein Families	Druggable Genome