FBP17 Polyclonal Antibody, AbBy Fluor® 647 Conjugated

Katalog-Nummer bs-13147R-BF647-20ul

Size : 20ul

Contact local distributor :


Telefonnummer :

FBP17 Polyclonal Antibody, AbBy Fluor® 647 Conjugated

Applications

  • WB
  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)

Reactivity

  • Xenopus laevis
  • Pufferfish

Predicted Reactivity

  • Human
  • Mouse
  • Rat
  • Dog
  • Cow
  • Sheep
  • Horse
  • Zebrafish
Overview
Catalog # bs-13147R-BF647
Product Name FBP17 Polyclonal Antibody, AbBy Fluor® 647 Conjugated
Applications WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Reactivity Xenopus laevis, Pufferfish
Predicted Reactivity Human, Mouse, Rat, Dog, Cow, Sheep, Horse, Zebrafish
Specifications
Conjugation AbBy Fluor® 647
Host Rabbit
Source KLH conjugated synthetic peptide derived from human FBP17
Immunogen Range 331-430/617
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 23048
Subcellular location Cytoplasm, Cell membrane
Synonyms FBP1; FBP17; FNBP1; FNBP1_HUMAN; Formin binding protein 1; Formin binding protein 17; Formin-binding protein 1; Formin-binding protein 17; hFBP17; KIAA0554; MGC126804.
Background FNBP1 is a 617 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one REM repeat and one SH3 domain. Expressed at high levels in respiratory, reproductive and urinary systems, as well as in brown adipose tissue and epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7 and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role in membrane tubulation and cytoskeletal reorganization during endocytosis. Additionally, FNBP1, which exists as four alternatively spliced isoforms, enhances Actin polymerization and promotes membrane invagination and the formation of tubules. Chromosomal aberrations in the FNBP1 gene are associated with acute leukemias, suggesting a role for defective FNBP1 in carcinogenesis.
Application Dilution
WB 1:300-5000
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200