Erythromycin [114-07-8]
Katalog-Nummer HY-B0220-1ml
Size : 10mM/1mL
Marke : MedChemExpress
Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research[3][4].
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Erythromycin Chemische Struktur
CAS. Nr. : 114-07-8
This product is a controlled substance and not for sale in your territory.
Based on 17 publication(s) in Google Scholar
Other Forms of Erythromycin:
- Erythromycin-d6 In-stock
- Erythromycin-d3 In-stock
- Erythromycin Ethylsuccinate In-stock
- Erythromycin stearate Angebot einholen
- Erythromycin lactobionate Angebot einholen
- Erythromycin (aspartate) Angebot einholen
- Erythromycin thiocyanate Angebot einholen
- Erythromycin A dihydrate Angebot einholen
- Erythromycin (Standard) Angebot einholen
- Erythromycin-13C,d3 Angebot einholen
Beschreibung |
Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research[3][4]. |
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IC50 & Target |
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In Vitro |
Erythromycin inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[4]
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In Vivo |
Erythromycin (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice[3]. Erythromycin (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg[3]. Erythromycin (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Klinische Studie |
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Molekulargewicht |
733.93 |
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Formel |
C37H67NO13 |
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CAS. Nr. |
114-07-8 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C[C@@H]([C@@H]([C@H](C(O[C@@H]1CC)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)(07)C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](C([C@@H]([C@@H](O)[C@@]1(O)C)C)=O)C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)(07)[C@@H]3O |
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Structure Classification |
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Initial Source |
Streptomyces erythreHs |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : ≥ 100 mg/mL (136.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.86% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.3625 mL | 6.8126 mL | 13.6253 mL | 34.0632 mL |
5 mM | 0.2725 mL | 1.3625 mL | 2.7251 mL | 6.8126 mL | |
10 mM | 0.1363 mL | 0.6813 mL | 1.3625 mL | 3.4063 mL | |
15 mM | 0.0908 mL | 0.4542 mL | 0.9084 mL | 2.2709 mL | |
20 mM | 0.0681 mL | 0.3406 mL | 0.6813 mL | 1.7032 mL | |
25 mM | 0.0545 mL | 0.2725 mL | 0.5450 mL | 1.3625 mL | |
30 mM | 0.0454 mL | 0.2271 mL | 0.4542 mL | 1.1354 mL | |
40 mM | 0.0341 mL | 0.1703 mL | 0.3406 mL | 0.8516 mL | |
50 mM | 0.0273 mL | 0.1363 mL | 0.2725 mL | 0.6813 mL | |
60 mM | 0.0227 mL | 0.1135 mL | 0.2271 mL | 0.5677 mL | |
80 mM | 0.0170 mL | 0.0852 mL | 0.1703 mL | 0.4258 mL | |
100 mM | 0.0136 mL | 0.0681 mL | 0.1363 mL | 0.3406 mL |