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> Enoxaparin [679809-58-6]

Enoxaparin [679809-58-6]

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Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19.

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Enoxaparin Chemische Struktur

Enoxaparin Chemische Struktur

CAS. Nr. : 679809-58-6

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Beschreibung

Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19[1][2][3].

In Vitro

Enoxaparin (0-70 µg/mL, 90 min) enhances AAT (alpha-1-antitrypsin) inhibition of both TMPRSS2 (Transmembrane Protease 2) activity and infection of hAEc (human airway epithelial cells) with HCoV-229E[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enoxaparin Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293T TMPRSS2 cells, hAEc
Concentration: 0, 8.8, 35, 70 µg/mL
Incubation Time: 90 min
Result: Significantly inhibited TMPRSS2 activity at the 90 min incubation period at 35 and 70 µg/mL, enhanced AAT inhibition of TMPRSS2 activity, and augmented AAT inhibition of HCoV-229E infection of hAEc.
In Vivo

Enoxaparin (1 mg/kg; SC; once every 6 h for 8 times) reduces oxidative damage, inflammation and astrocytosis following TBI (traumatic brain injury) in the rat[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (350-450 g, TBI-treated)[2]
Dosage: 0 mg/kg, 1 mg/kg
Administration: SC, once every 6 h, starting at 1 h, and finishing at 43 h after the TBI induction.
Result: Significantly decreased the hippocampal TBARS and oxidized protein levels, COX-2 overexpression and reactive gliosis, but it did not influence the SOD and GSH-Px activities, pro-IL-1β and active caspase-3 overexpressions as well as neurodegeneration following TBI. Reduce oxidative damage, inflammation and astrocytosis following TBI in the rat.
Klinische Studie
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

[Enoxaparin]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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Enoxaparin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enoxaparin679809-58-6PK 10169 LovenoxPK10169PK-10169Factor XaThrombinSARS-CoVFxaSARS coronavirusLiver fibrosisThioacetamidecoronavirusinfectionCOVID-19traumatic brain injuryneuroprotectiveInflammationblood clotsacute coronary syndromesInhibitorinhibitorinhibit

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Inquiry Information

Produktname:
Enoxaparin
Art. -Nr.:
HY-109509
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