Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Deoxycholic acid [83-44-3]
Katalog-Nummer T2965-1mL
Size : 1mL
Marke : TargetMol
Contact local distributor :
Telefonnummer : +1 850 650 7790
Deoxycholic acid
Catalog No. T2965 CAS 83-44-3
Synonyms: Cholorebic, Deoxycholate, Desoxycholic acid, Cholanoic Acid, Cholerebic
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Deoxycholic acid, CAS 83-44-3
| Description | Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent. |
| In vitro | Deoxycholic acid inhibits miR-21 expression in primary rat hepatocytes in a dose-dependent manner, and increases miR-21 pro-apoptotic target programmed cell death 4 (PDCD4) and apoptosis. Deoxycholic acid decreases NF-κB activity, shown to represent an upstream mechanism leading to modulation of the miR-21/PDCD4 pathway[1]. |
| In vivo | miR-21 expression is down-regulated upon short exposures to Deoxycholic acid, as is the downstream pathway, with concomitant PIDD processing and activation of caspase-2, which contributes to DCA-induced liver damage[1]. |
| Cell Research | Primary rat hepatocytes were isolated from male rats (100 to 150 g) by collagenase perfusion. After isolation, hepatocytes were resuspended in complete Williams E medium and plated on BD Primaria™ culture dishes at 5 × 104 cells/cm2. Cells are kept at 37 °C in a humidified atmosphere of 5% CO2 for 4-6 h to allow attachment. Plates are then washed with phosphate buffered saline (PBS) 1× in order to remove dead cells and incubated in Williams E medium supplemented with 25 to 200 μM DCA or no addition (control) for 24 h. Primary rat hepatocytes are processed for total RNA and protein isolation, cell viability, cytotoxicity and caspase activity assays and Hoechst staining. (Only for Reference) |
| Synonyms | Cholorebic, Deoxycholate, Desoxycholic acid, Cholanoic Acid, Cholerebic |
| Molecular Weight | 392.57 |
| Formula | C24H40O4 |
| CAS No. | 83-44-3 |
Storage
Solubility Information
DMSO: 72 mg/mL (183.4 mM)
Ethanol: 56 mg/mL (142.6 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
References and Literature