CR2 Antibody
Katalog-Nummer OAEE00728
Size : 100tests(T100)
Marke : Aviva Systems Biology
Contact local distributor :
Telefonnummer : +1 850 650 7790
CR2 Antibody
| Datasheets/Manuals | Printable datasheet for CR2 Antibody |
|---|
| Predicted Species Reactivity | Bovine|Dog|Human|Porcine |
|---|---|
| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | LT21 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | R-PE |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | IM9 human B-lymphoblastoid cell line |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 20 ul / test |
| Specificity | The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells. HLDA VI; WS Code B CD21.1 |
| Formulation | PE |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Filatov AV, Krotov GI, Zgoda VG, Volkov Y: Fluorescent immunoprecipitation analysis of cell surface proteins: a methodology compatible with mass-spectrometry. J Immunol Methods. 2007 Jan 30;319(1-2):21-33. Faldyna M, Samankova P, Leva L, Cerny J, Oujezdska J, Rehakova Z, Sinkora J: Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs. Vet Immunol Immunopathol. 2007 Sep 15;119(1-2):56-62. Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997). Singh A, Blank M, Shoenfeld Y, Illges H: Antiphospholipid syndrome patients display reduced titers of soluble CD21 in their sera irrespective of circulating anti-beta2-glycoprotein-I autoantibodies. Rheumatol Int. 2008 Jan 3 Zabel MD, Heikenwalder M, Prinz M, Arrighi I, Schwarz P, Kranich J, von Teichman A, Haas KM, Zeller N, Tedder TF, Weis JH, Aguzzi A: Stromal complement receptor CD21/35 facilitates lymphoid prion colonization andpathogenesis. J Immunol. 2007 Nov 1;179(9):6144-52. Kasprzak A, Spachacz R, Wachowiak J, Stefanska K, Zabel M: Epstein-Barr virus (EBV) infection in B-cell non-Hodgkin's lymphomas in children: virus latency and its correlation with CD21 and CD23 molecules. Folia Histochem Cytobiol. 2007;45(3):169-79. Twohig J, Kulik L, Haluszczak C, Reuter J, Rossbach A, Bull M, Holers VM, Marchbank KJ: Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3. Mol Immunol. 2007 Jul;44(13):3434-44. Roozendaal R, Carroll MC: Complement receptors CD21 and CD35 in humoral immunity. Immunol Rev. 2007 Oct;219:157-66. |
|---|---|
| Gene Symbol | CR2 |
| Gene Full Name | complement C3d receptor 2 |
| Alias Symbols | C3DR, CD21, Complement C3d receptor, complement component (3d/Epstein Barr virus) receptor 2, complement component 3d receptor 2, complement receptor type 2, CR, CVID7, EBV receptor, Epstein-Barr virus receptor, SLEB9. |
| NCBI Gene Id | 1380 |
| Protein Name | Complement receptor type 2 |
| Description of Target | Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047). |
| Uniprot ID | P20023 |
| Protein Accession # | NP_001006659.1; NP_001868.2 |
| Nucleotide Accession # | NM_001006658.2; NM_001877.4 |
