store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cholesterol [57-88-5]
Katalog-Nummer T0760-20mg
Size : 20mg
Marke : TargetMol
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Cholesterol
Catalog No. T0760 CAS 57-88-5
Synonyms: Cholesterin, Cholesteryl alcohol
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
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Cholesterol, CAS 57-88-5
| Description | Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids. |
| In vitro | Within the body, cholesterol can be reabsorbed. It is metabolized into the gastrointestinal tract in an unesterified form via the bile secreted by the liver. Approximately 50% of cholesterol metabolism typically involves reabsorption by the small intestine back into the bloodstream. |
| In vivo | The tetrahydric structure of cholesterol is advantageous in reducing the fluidity of the cell membrane, with all molecules in the trans conformation except for the rigid plane of the cholesterol side chain. This structure of cholesterol decreases the permeability of the plasma membrane to neutral solutes, protons, and sodium ions. Cholesterol serves as a precursor for the biosynthesis of bile acids, steroidal hormones, and vitamin D. It regulates membrane fluidity within physiological temperature ranges. Cholesterol's hydroxyl group interacts with the polar head groups of sphingomyelin and phospholipids, while its bulky hydrocarbon chain and steroidal structure are embedded within the membrane among the non-polar fatty acid chains of other lipids. By interacting with the fatty acid chains of phospholipids, cholesterol increases membrane packing, thereby reducing membrane fluidity. |
| Source |
| Synonyms | Cholesterin, Cholesteryl alcohol |
| Molecular Weight | 386.664 |
| Formula | C27H46O |
| CAS No. | 57-88-5 |
Storage
Solubility Information
DMSO: Insoluble
Ethanol: 10 mg/mL(25.86 mM)
H2O: Insoluble
References and Literature
1. Sengupta S, et al. Cholesterol-dependent plasma membrane order (Lo) is critical for antigen-specific clonal expansion of CD4+ T cells. Sci Rep. 2021 Jul 7;11(1):13970. 2. Lim SC, et al. Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. Int J Oncol. 2014 Mar;44(3):805-11. 3. Tawara K, et al. Mode of action of probucol in reducing serum cholesterol in mice. Jpn J Pharmacol. 1986 Jan;40(1):123-33. 4. Díaz-Zagoya JC, et al. Effects of high rosuvastatin doses on hepatocyte mitochondria of hypercholesterolemic mice. Sci Rep. 2021 Aug 4;11(1):15809.
Citations
1. Qiao S, Bao L, Wang K, et al. Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis. Cell Reports. 2020, 32(6): 108005 2. Fang X X, Wei P, Zhao K, et al.Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.Journal of Cell Biology.2024, 223(4).
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Keywords
Cholesterol 57-88-5 Endocrinology/Hormones Immunology/Inflammation Metabolism ROR Endogenous Metabolite MRP Estrogen Receptor/ERR ERRα AKT SREBP2 exocytic Cholesterin signaling insulin Inhibitor inhibit IRS-1 unesterified Cholesteryl alcohol phosphorylation Diabetes transporters inhibitor