Flow Cytometry (≤ 0.2 µg/106 cells): Identification and enumeration of CD8+cells. (Ref.2)
Reactivity
Chicken
Antibody Host
Mouse
Isotype
IgG1
Clonality
Monoclonal
Immunogen
Chicken thymocytes and Ig-negative blood leukocytes.
Specificity
This antibody recognizes alpha chain (34-kDa) of Chicken CD8. The monoclonal antibody CT-8 recognizes the CD8α chain and has been shown to react to a polymorphic determinant in Turkey.
Buffer
PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: PE State: Liquid purified Ig fraction. Label: R-Phycoerythrin
Concentration
lot specific
Conjugation
PE
Storage
Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 is expressed on most thymocytes and approximately 1/3 of peripheral blood T cells in humans. CD8 alpha/beta heterodimers are expressed only on TCR alpha/beta T cells, whereas CD8 alpha homodimers can be expressed on alpha/beta and gamma/delta T cells and some NK cells in humans. The pattern of expression in other species has not been well documented.
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