CD58 Antibody
Katalog-Nummer OAEE00926
Size : 100tests(T100)
Marke : Aviva Systems Biology
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Telefonnummer : +1 850 650 7790
CD58 Antibody
| Datasheets/Manuals | Printable datasheet for CD58 Antibody |
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| Predicted Species Reactivity | Human|Porcine |
|---|---|
| Product Format | Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | MEM-63 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | APC |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | NALM-6 human pre-B cell line |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 10 ul / test |
| Specificity | The antibody MEM-63 reacts with CD58 (LFA-3), a 40-70 kDa glycoprotein distributed over many tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts. HLDA VI; WS Code AS A047 |
| Formulation | APC |
| Storage Buffer | The reagent is provided in Tris buffered saline (TBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997). Sheng L, Li J, Qi BT, Ji YQ, Meng ZJ, Xie M: Investigation on correlation between expression of CD58 molecule and severity of hepatitis B. World J Gastroenterol. 2006 Jul 14;12(26):4237-40. Ariel O, Kukulansky T, Raz N, Hollander N: Distinct membrane localization and kinase association of the two isoforms of CD58. Cell Signal. 2004 Jun;16(6):667-73. Veltroni M, De Zen L, Sanzari MC, Maglia O, Dworzak MN, Ratei R, Biondi A, Basso G, Gaipa G; I-BFM-ALL-FCM-MRD-Study Group: Expression of CD58 in normal, regenerating and leukemic bone marrow B cells:implications for the detection of minimal residual disease in acute lymphocytic leukemia. Haematologica. 2003 Nov;88(11):1245-52. Bayas MV, Schulten K, Leckband D: Forced detachment of the CD2-CD58 complex. Biophys J. 2003 Apr;84(4):2223-33. |
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| Gene Symbol | CD58 |
| Gene Full Name | CD58 molecule |
| Alias Symbols | ag3, CD58 antigen, (lymphocyte function-associated antigen 3), LFA-3, LFA3, lymphocyte function-associated antigen 3, surface glycoprotein LFA-3. |
| NCBI Gene Id | 965 |
| Protein Name | Lymphocyte function-associated antigen 3 |
| Description of Target | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. |
| Uniprot ID | P19256 |
| Protein Accession # | NP_001138294.1; NP_001770.1 |
| Nucleotide Accession # | NM_001144822.1; NM_001779.2 |
