Calyculin A [101932-71-2]

Special Hazard: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.

Storage: Store at or below -20 ºC in the dark. Solubility: Soluble in DMSO and ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.

• LC Labs is the primary worldwide source of Calyculin A for laboratory research
• > 40 distributors and resellers worldwide offer our Calyculin A
• Thousands of labs have used our Calyculin A
• Very potent inhibitor (Ki = ca. 0.1 nM) with high specificity for the PP-1 and PP-2 classes of protein serine/threonine phosphatase. Ishihara, H., et al. "Calyculin A and okadaic acid: inhibitors of protein phosphatase activity." Biochem. Biophys. Res. Comm. 159: 871-877 (1989).
• Potent non-phorbol type tumor promoter. Suganuma, M., et al. "Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin." Cancer Res. 50: 3521-3525 (1990).
• Please request Technical Note #19 for additional information
• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.