Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azithromycin hydrate [117772-70-0]
Katalog-Nummer T1419-20mg
Size : 20mg
Marke : TargetMol
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Azithromycin hydrate
Catalog No. T1419 CAS 117772-70-0
Synonyms: CP-62993 dihydrate, Azithromycin dihydrate
Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Azithromycin hydrate, CAS 117772-70-0
| Description | Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis. |
| In vivo | Azithromycin (50 mg/kg) does not alter bronchoalveolar lavage inflammatory parameters or LDH levels in a mouse asthma exacerbation model. It also does not induce general inflammation or LDH release, but enhances interferon-stimulated gene expression and MDA5, a pattern recognition receptor, effectively lowering viral load without affecting RIG-I in exacerbating mice[2]. |
| Cell Research | THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. |
| Synonyms | CP-62993 dihydrate, Azithromycin dihydrate |
| Molecular Weight | 785.03 |
| Formula | C38H72N2O12·2H2O |
| CAS No. | 117772-70-0 |
Storage
Solubility Information
H2O: 10 mg/mL (12.73 mM)
DMSO: 93 mg/mL (118.5 mM)
Ethanol: 93 mg/mL (118.5 mM)
References and Literature
1. Peters DH, et al. Drugs, 1992, 44(5), 750-799. 2. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.